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Percutaneous umbilical cord blood sampling
Percutaneous umbilical cord blood sampling (PUBS), also called cordocentesis, fetal blood sampling, or umbilical vein sampling is a diagnostic genetic test that examines blood from the fetal umbilical cord to detect fetal abnormalities. Fetal and maternal blood supply are typically connected in utero with one vein and two arteries to the fetus. The umbilical vein is responsible for delivering oxygen rich blood to the fetus from the mother; the umbilical arteries are responsible for removing oxygen poor blood from the fetus. This allows for the fetus’ tissues to properly perfuse. PUBS provides a means of rapid chromosome analysis and is useful when information cannot be obtained through amniocentesis, chorionic villus sampling, or ultrasound (or if the results of these tests were inconclusive); this test carries a significant risk of complication and is typically reserved for pregnancies determined to be at high risk for genetic defect. It has been used with mothers with immune thrombocytopenic purpura.
==History==
PUBS is a type of fetal blood sampling which was originally developed to determine the presence of hereditary abnormalities. Currently, it can detect a number of abnormalities including pH levels, oxygen levels, chromosomal issues, and infections. PUBS dates back to 1964 when Freda and Adamsons reported the removal of a uterus containing a fetus who had a buildup of fluid and ended up dying; however, this was one of the first procedures that showed promise for current day PUBS. Valenti hypothesized in 1972 that the procedure he used to obtain fetal tissue could be used to obtain fetal blood, and in 1973, he was able to sample fetal vessels; fetoscopy was used and refined between 1974 and 1983 as a prenatal test to determine fetal status as well as obtain fetal blood and perform transfusions in some cases.〔 Fetoscopy is a procedure in which a device is inserted through the abdomen of the mother in order to visualize the fetus. The first documented use of PUBS came in 1983 by Daffos and colleagues who sampled blood from an umbilical vein with a needle and monitored its maneuvers with an ultrasound.〔 PUBS has presented a more successful and less dangerous alternative to fetoscopy, which had a miscarriage risk of 5-10%.〔
With the development of modern medicine and new techniques, PUBS is not used often except when rapid diagnosis and decisions must be made in regards to the fetus and suspected abnormalities suspected. PUBS has been predominantly replaced by Fluorescence in situ hybridization (FISH) which is a more detailed investigation of chromosomal abnormalities.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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